Latest & greatest articles for geriatrics

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Top results for geriatrics

141. Acupuncture vs Noninsertive Sham Acupuncture in Aging Patients with Degenerative Lumbar Spinal Stenosis: A Randomized Controlled Trial Full Text available with Trip Pro

Acupuncture vs Noninsertive Sham Acupuncture in Aging Patients with Degenerative Lumbar Spinal Stenosis: A Randomized Controlled Trial Acupuncture is commonly used to treat degenerative lumbar spinal stenosis in Asian countries. However, rigorous data regarding the efficacy and safety of acupuncture for aging patients are currently lacking.Eighty patients older than 50 years were assigned randomly to the acupuncture group or the noninsertive sham acupuncture for 24 treatments over an 8-week

2020 EvidenceUpdates

142. Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial Full Text available with Trip Pro

results compared with open reduction and internal fixation (ORIF) using an angular stable plate. Methods: The DelPhi trial is a randomized controlled trial comparing reverse TSA with ORIF for displaced proximal humeral fractures (OTA/AO types 11-B2 and 11-C2) in elderly patients (65 to 85 years of age). The primary outcome measure was the Constant score at a 2-year follow-up. The secondary outcome measures included the Oxford Shoulder Score and radiographic evaluation. Results were reported (...) Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial Reverse Shoulder Arthroplasty Is Superior to Plate Fixation at 2 Years for Displaced Proximal Humeral Fractures in the Elderly: A Multicenter Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy

2020 EvidenceUpdates

143. Association between preadmission frailty and care level at discharge in older adults undergoing emergency laparotomy (Abstract)

with increased dependence at the time of discharge.The ELF study was a UK-wide multicentre prospective cohort study of older patients (65 years or more) undergoing emergency laparotomy during March and June 2017. The objective was to establish whether preoperative frailty was associated with increased care level at discharge compared with preoperative care level. The analysis used a multilevel logistic regression adjusted for preadmission frailty, patient age, sex and care level.A total of 934 patients were (...) included from 49 hospitals. Mean(s.d.) age was 76·2(6·8) years, with 57·6 per cent women; 20·2 per cent were frail. Some 37·4 per cent of older adults had an increased care level at discharge. Increasing frailty was associated with increased discharge care level, with greater predictive power than age. The adjusted odds ratio for an increase in care level was 4·48 (95 per cent c.i. 2·03 to 9·91) for apparently vulnerable patients (Clinical Frailty Score (CFS) 4), 5·94 (2·54 to 13·90) for those mildly

2020 EvidenceUpdates

144. Epilepsy in older people. (Abstract)

Epilepsy in older people. Globally, as populations age there will be challenges and opportunities to deliver optimal health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent seizures, is common in older adults (aged >65 years) and yet has received comparatively little attention in this age group. In this Review, we evaluate the underlying causes of epilepsy in older people, explore difficulties in establishing a diagnosis of epilepsy in this population (...) , discuss appropriate antiseizure medications, and evaluate potential surgical treatment options. We consider cognitive, psychological, and psychosocial comorbidities and the effect that epilepsy might have on an older person's broader social or care network in high-income versus middle-income and low-income countries. We emphasise the need for clinical trials to be more inclusive of older people with epilepsy to help inform therapeutic decision making and discuss whether measures to improve vascular

2020 Lancet

145. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. (Abstract)

Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Vitamin and mineral deficiencies, particularly those of iron, vitamin A, and zinc, affect more than two billion people worldwide. Young children are highly vulnerable because of rapid growth and inadequate dietary practices. Multiple micronutrient powders (MNPs) are single-dose packets containing multiple vitamins and minerals in powder form, which are mixed into any semi (...) -solid food for children six months of age or older. The use of MNPs for home or point-of-use fortification of complementary foods has been proposed as an intervention for improving micronutrient intake in children under two years of age. In 2014, MNP interventions were implemented in 43 countries and reached over three million children. This review updates a previous Cochrane Review, which has become out-of-date.To assess the effects and safety of home (point-of-use) fortification of foods with MNPs

2020 Cochrane

146. Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement. Full Text available with Trip Pro

Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement. Dementia (also known as major neurocognitive disorder) is defined by a significant decline in 1 or more cognitive domains that interferes with a person's independence in daily activities. Dementia affects an estimated 2.4 to 5.5 million individuals in the United States, and its prevalence increases with age.To update its 2014 recommendation, the US Preventive Services Task Force (...) (USPSTF) commissioned a review of the evidence on screening for cognitive impairment, including mild cognitive impairment and mild to moderate dementia, in community-dwelling adults, including those 65 years or older residing in independent living facilities.This recommendation applies to community-dwelling older adults 65 years or older, without recognized signs or symptoms of cognitive impairment.The USPSTF concludes that the evidence is lacking, and the balance of benefits and harms of screening

2020 JAMA

147. Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial. (Abstract)

mortality at 90 days in ICU patients aged 65 years or older with vasodilatory hypotension.A multicenter, pragmatic, randomized clinical trial was conducted in 65 ICUs in the United Kingdom and included 2600 randomized patients aged 65 years or older with vasodilatory hypotension (assessed by treating clinician). The study was conducted from July 2017 to March 2019, and follow-up was completed in August 2019.Patients were randomized 1:1 to vasopressors guided either by MAP target (60-65 mm Hg, permissive (...) Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial. Vasopressors are commonly administered to intensive care unit (ICU) patients to raise blood pressure. Balancing risks and benefits of vasopressors is a challenge, particularly in older patients.To determine whether reducing exposure to vasopressors through permissive hypotension (mean arterial pressure [MAP] target, 60-65 mm Hg) reduces

2020 JAMA

148. Failure of Traditional Risk Factors to Adequately Predict Cardiovascular Events in Older Populations

patients. Among those aged 85 years and older, some traditional risk factors were not associated with ASCVD events. Better risk models are needed to appropriately inform treatment decision making for the growing population of older adults. Keywords: model validation; older adults; risk heterogeneity; risk prediction. © 2020 The American Geriatrics Society. Similar articles MG Nanna et al. J Gen Intern Med. 2019. PMID 31667745. The performance of the PCE for ASCVD risk estimation in older adults (...) to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation J Am Geriatr Soc Actions 2020 Jan 20 [Online ahead of print] Failure of Traditional Risk Factors to Adequately Predict Cardiovascular Events in Older Populations , , , , , Affiliations Expand Affiliations 1 Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio. 2 Department of Quantitative Health

2020 EvidenceUpdates

149. Comparison of the Effect of Age (< 75 Versus >/= 75) on the Efficacy and Safety of Dual Therapy (Dabigatran+Clopidogrel or Ticagrelor) Versus Triple Therapy (Warfarin+Aspirin+Clopidogrel or Ticagrelor) in Patients With Atrial Fibrillation After Percutaneo Full Text available with Trip Pro

to treatment, 1,026 (37.7%) were categorized into older and 1,699 (62.3%) into younger age groups. Dabigatran 110 mg dual therapy lowered bleeding risk versus warfarin triple therapy in older (hazard ratio [HR] 0.67; 95% confidence interval [CI] 0.51 to 0.89) and younger patients (HR 0.40; 95% CI 0.30 to 0.54); interaction p value: 0.0125. Dabigatran 150 mg dual therapy lowered bleeding risk versus warfarin triple therapy in younger patients (HR 0.57; 95% CI 0.44 to 0.74), whereas no benefit could (...) Comparison of the Effect of Age (< 75 Versus >/= 75) on the Efficacy and Safety of Dual Therapy (Dabigatran+Clopidogrel or Ticagrelor) Versus Triple Therapy (Warfarin+Aspirin+Clopidogrel or Ticagrelor) in Patients With Atrial Fibrillation After Percutaneo Comparison of the Effect of Age ( - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History

2020 EvidenceUpdates

150. Older adults: cost-effective commissioning

and implementing services to support older people's healthy ageing. Published 28 January 2020 From: Documents Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need a version of this document in a more accessible format, please email . Please tell us what format you need. It will help us if you say what assistive technology you use. Ref: PHE publications gateway reference GW-1008 If you use assistive technology (such as a screen reader) and need (...) on identified interventions to support older people, generated through a literature review. The return on investment (ROI) tool: can be adapted to local conditions presents results showing the economic benefits of each intervention has a built-in user guide Local authorities and clinical commissioning groups can use these resources to improve the provision of services for older people. Published 28 January 2020 Related content Explore the topic Is this page useful? Thank you for your feedback Help us

2020 Public Health England

151. Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours

Plerixafor (Mozobil) - children aged 1 year to <18 years with lymphoma or solid malignant tumours Published 10 February 2020 1 Product update SMC2249 plerixafor 20mg/mL solution for injection (Mozobil®) Sanofi Aventis 10 January 2020 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated (...) submission plerixafor (Mozobil®) is accepted for use within NHSScotland. Indication under review: in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in children aged 1 year to <18 years with lymphoma or solid malignant tumours, either: - pre-emptively, when circulating stem cell count on the predicted day of collection after adequate mobilisation with G-CSF

2020 Scottish Medicines Consortium

152. Testosterone Treatment in Adult Men with Age-Related Low Testosterone Full Text available with Trip Pro

, Nankin HR , Spark RF , et al American Association of Clinical Endocrinologists American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients—2002 update. Endocr Pract 2002 Nov-Dec 8 440 56 Wu FC , Tajar A , Beynon JM , et al EMAS Group Identification of late-onset hypogonadism in middle-aged and elderly men. N Engl J Med 2010 363 123 35 Bassil N , Morley JE . Late-life onset hypogonadism: a review (...) . Clin Geriatr Med 2010 26 197 222 Nguyen CP , Hirsch MS , Moeny D , et al Testosterone and “Age-related hypogonadism”—FDA concerns. N Engl J Med 2015 373 689 91 Diem SJ , Greer NL , MacDonald R , et al Efficacy and safety of testosterone treatment in men: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Intern Med 7 January 2020 [Epub ahead of print] Qaseem A , Kansagara D , Lin JS , et al Clinical Guidelines Committee of the American College

2020 American College of Physicians

153. Validation of the Elderly Risk Assessment Index in the Emergency Department (Abstract)

Validation of the Elderly Risk Assessment Index in the Emergency Department The Elderly Risk Assessment (ERA) score is a validated index for primary care patients that predict hospitalizations, mortality, and Emergency Department (ED) visits. The score incorporates age, prior hospital days, marital status, and comorbidities. Our aim was to validate the ERA score in ED patients.Observational cohort study of patients age ≥ 60 presenting to an academic ED over a 1-year period. Regression analyses (...) were performed for associations with outcomes (hospitalization, return visits and death). Medians, interquartile range (IQR), odds ratios (OR) and 95% confidence intervals (CI) were calculated.The cohort included 27,397 visits among 18,607 patients. Median age 74 years (66-82), 48% were female and 59% were married. Patients from 54% of visits were admitted to the hospital, 16% returned to the ED within 30 days, and 18% died within one year. Higher ERA scores were associated with: hospital admission

2020 EvidenceUpdates

154. Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial

Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features (...) a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation J Clin Oncol Actions , 38 (3), 248-256 2020 Jan 20 Treatment of Older Patients With Mantle Cell Lymphoma (MCL): Long-Term Follow-Up of the Randomized European MCL Elderly Trial , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 University Medical Center Groningen

2020 EvidenceUpdates

155. Developing an all-age response to meet the age-specific needs of service users

Developing an all-age response to meet the age-specific needs of service users NHS England » Developing an all-age response to meet the age-specific needs of service users Search Search Menu Developing an all-age response to meet the age-specific needs of service users Document first published: 22 January 2020 Page updated: 22 January 2020 Topic: Publication type: Document PDF 476 KB 14 pages

2020 NHS England

156. Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children: prospective population-based study

Incident psychiatric comorbidity following stress disorder diagnoses in Danish school-aged children: prospective population-based study Incident Psychiatric Comorbidity Following Stress Disorder Diagnoses in Danish School-Aged Children: Prospective Population-Based Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other (...) characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Br J Psychiatry Actions , 1-6 2019 Nov 22 [Online ahead of print] Incident Psychiatric Comorbidity Following Stress Disorder Diagnoses in Danish School-Aged Children: Prospective Population-Based Study , , , , , , Affiliations Expand Affiliations 1 Research Associate

2020 EvidenceUpdates

157. Physical Activity: Digital Health Interventions for Adults 55 Years and Older

Studies The number of studies and publications do not always correspond (e.g., a publication may include several studies or one study may be explained in several publications). . Bickmore TW, Silliman RA, Nelson K, Cheng DM, Winter M, et al.. A randomized controlled trial of an automated exercise coach for older adults. J Am Geriatr Soc 2013;61:1676–83. Freene N. Physiotherapist-led home-based physical activity program versus community group exercise for middle-aged adults: quasi-experimental (...) , Castro CM, et al. Promoting physical activity through hand-held computer technology. Am J Prev Med 2008;34:138–42. King AC, Bickmore TW, Campero MI, Pruitt LA, Yin JL. Employing virtual advisors in preventive care for underserved communities: results from the COMPASS study. J Health Commun 2013b;18:1449–64. Kolt GS, Schofield GM, Kerse N, Garrett N, Oliver M. Effect of telephone counseling on physical activity for low-active older people in primary care: a randomized, controlled trial. J Am Geriatr

2020 Community Preventive Services Task Force

158. Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Full Text available with Trip Pro

in elderly patients after surgery and is associated with poor outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on the incidence of delirium in elderly patients undergoing major surgery. Methods: This was a randomized double-blind placebo-controlled trial. Elderly patients (aged 60 years or more) scheduled to undergo major non-cardiac surgery were randomized into two groups. Patients in the intervention group received a loading dose of dexmedetomidine 0·6 μg/kg 10 min (...) Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery Randomized Clinical Trial of Intraoperative Dexmedetomidine to Prevent Delirium in the Elderly Undergoing Major Non-Cardiac Surgery - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced

2020 EvidenceUpdates

159. Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial (Abstract)

inhibitor valproate and all-trans retinoic acid (ATRA) in treatment-naive elderly patients with acute myeloid leukemia (AML).Two hundred patients (median age, 76 years; range, 61-92 years) ineligible for induction chemotherapy received decitabine (20 mg/m2 intravenously, days 1 to 5) alone (n = 47) or in combination with valproate (n = 57), ATRA (n = 46), or valproate + ATRA (n = 50). The primary endpoint was objective response, defined as complete and partial remission, tested at a one-sided (...) Valproate and Retinoic Acid in Combination With Decitabine in Elderly Nonfit Patients With Acute Myeloid Leukemia: Results of a Multicenter, Randomized, 2 x 2, Phase II Trial DNA-hypomethylating agents are studied in combination with other epigenetic drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in myeloid neoplasias. A randomized, phase II trial with a 2 × 2 factorial design was conducted to investigate the effects of the histone deacetylase

2020 EvidenceUpdates

160. The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial Full Text available with Trip Pro

The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial The CHIRPY DRAGON Intervention in Preventing Obesity in Chinese Primary-School--Aged Children: A Cluster-Randomised Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced (...) characters Choose a collection: Unable to load your collection due to an error Add Cancel Add to My Bibliography My Bibliography Unable to load your delegates due to an error Add Cancel Actions Cite Share Permalink Copy Page navigation Randomized Controlled Trial PLoS Med Actions , 16 (11), e1002971 2019 Nov 26 eCollection Nov 2019 The CHIRPY DRAGON Intervention in Preventing Obesity in Chinese Primary-School--Aged Children: A Cluster-Randomised Controlled Trial , , , , , , , , , , , Affiliations Expand

2020 EvidenceUpdates