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Top results for geriatrics

41. Ivacaftor (cystic fibrosis, 6 years and older, with G551D mutation) - Addendum to Commission A19-65

]. In its dossier [2], the pharmaceutical company (hereinafter referred to as “the company”) presented results of the randomized controlled trials (RCTs) VX08-770-102 and VX08-770-103 for the assessment of the added benefit of ivacaftor in the treatment of cystic fibrosis in patients aged 6 years and older and weighing 25 kg or more who have the G551D gating mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. These studies were included in the benefit assessment (...) , and no information at all on prior and concomitant medication for the relevant subpopulation of the VX08-770-103 study. Hence, the certainty of conclusions of the study results was reduced both for conclusions on patients aged 12 years and older based on the VX08-770-102 study and for children between 6 and 11 years of age based on the VX08-770-103 study. In its comments, the company presented supplementary information on concomitant antibiotic treatment in the studies VX08-770-102 and VX08-770-103, which went

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

42. Ivacaftor (combination with tezacaftor/ivacaftor, cystic fibrosis, 12 years and older, with F508del mutation, heterozygous) - Addendum to Commission A19-71

Table 3: Table of the company from the comments: results of the VX14-661-110 study for patients aged 12 years and older who are heterozygous for the F508del mutation in the CFTR gene 9 Addendum A20-06 Version 1.0 Ivacaftor – Addendum to Commission A19-71 30 January 2020 Institute for Quality and Efficiency in Health Care (IQWiG) - v - List of figures Page Figure 1: Treatment sequences of the VX14-661-108 study and analysis groups of the VX14-661-110 extension study 4 Addendum A20-06 Version 1.0 (...) (CF) aged 12 years and older who are heterozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Due to the treatment duration of only 8 weeks, the study was not included in the benefit assessment, but the short-term results were presented as supplementary information. For the outcome “serious adverse events (SAEs)”, the company had presented analyses that included events that can be both symptoms of the underlying disease and side effects

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

43. Serious harms with long-term PPI use in older adults

groups all agree that they should be prescribed at the lowest dose and for the shortest duration appropriate to the condition treated. However, PPI use continues to expand. Between 2000 and 2018 BC’s population grew by 20%, but use of PPIs increased by 257%. In 2018, 442,559 British Columbians (9% of the population) filled at least one prescription for a PPI. 1 Long-term use of PPIs in older adults We examined use of PPIs from 2008-2018 in people age 65 or older who filled a PPI prescription in BC (...) that net benefits exceed harms during long-term use in older people. Y et despite multiple signals of serious harm, 88% of people over age 65 taking PPIs in BC during 2018 had long-term exposure. Associations detected in observational studies are not proof of causation, but insisting on RCT evidence for fatal and serious adverse events from medication use contravenes modern stan- dards in pharmacovigilance. The standard levels of evidence expected to confirm treatment benefits are not equally appropri

2020 Therapeutics Letter

44. AGS Position Statement: Resource Allocation Strategies and Age-Related Considerations in the COVID-19 Era and Beyond

of the American Geriatrics Society (AGS). It is intended to inform stakeholders including hospitals, health systems, and policymakers about ethical considerations to consider when developing strategies for allocating scarce resources during an emergency involving older adults. Members of the AGS Ethics Committee collaborated with interprofessional experts in ethics, law, nursing, and medicine (including geriatrics, palliative care, emergency medicine, and pulmonology/critical care) to conduct a structured (...) Strategies and Age-Related Considerations in the COVID-19 Era and Beyond Enter PIN * × PIN Subscriprion Subscription is completed successfully. Click OK button to go to MyLibrary page. Product Type : Guidelines, Recommendations & Position Statements Language : ENGLISH Publisher : American Geriatrics Society Year of publication : 2020 DESCRIPTION Disclaimer These recommendations published by The American Geriatrics Society (AGS) incorporate data obtained from a literature review of the most recent studies

2020 American Geriatrics Society

45. Frailty status predicts futility of cardiopulmonary resuscitation in older adults

escalation plans, as it becomes more widespread, larger scale observations using prospective assessments of frailty may become feasible. Keywords: cardiac-arrest; cardiopulmonary resuscitation; frailty; older people; resuscitation. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. Similar articles Wharton C, King E, MacDuff A. Wharton C, et al. Resuscitation. 2019 Oct (...) Permalink Copy Page navigation Age Ageing Actions . 2020 Jun 5;afaa104. doi: 10.1093/ageing/afaa104. Online ahead of print. Frailty status predicts futility of cardiopulmonary resuscitation in older adults , , , , Affiliations Expand Affiliations 1 North Bristol NHS Trust, University College London, London, UK. 2 North Bristol NHS Trust, Bristol, UK. 3 Gloucestershire Hospitals, NHS Foundation Trust, Gloucester, UK. 4 North Bristol NHS Trust, University of Bristol, Bristol, UK. PMID: 32500916 DOI: Item

2020 EvidenceUpdates

46. DOACs Versus VKAs in Older Adults Treated for Acute Venous Thromboembolism: Systematic Review and Meta-Analysis

study. Am J Med. 2014;127:530-537.e3. Kampfen P, Mean M, Limacher A, et al. Risk of falls and bleeding in elderly patients with acute venous thromboembolism. J Intern Med. 2014;276:378-386. Johnson SA, Eleazer GP, Rondina MT. Pathogenesis, diagnosis, and treatment of venous thromboembolism in older adults. J Am Geriatr Soc. 2016;64:1869-1878. Sterne JA, Bodalia PN, Bryden PA, et al. Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease (...) RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation J Am Geriatr Soc Actions . 2020 May 22. doi: 10.1111/jgs.16549. Online ahead of print. DOACs Versus VKAs in Older Adults Treated for Acute Venous Thromboembolism: Systematic Review and Meta-Analysis , , , , , Affiliations Expand Affiliations 1 Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA. 2 Division of Cardiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA. 3 Evidence-based

2020 EvidenceUpdates

47. Psychotherapy for Depression Across Different Age Groups: A Systematic Review and Meta-analysis

duplicates, 16 756 records were screened and 2608 full-text articles were screened. Of these, 366 trials (36 702 patients) with 453 comparisons between a therapy and a control condition were included in the qualitative analysis, including 13 (3.6%) in children (13 years and younger), 24 (6.6%) in adolescents (≥13 to 18 years), 19 (5.2%) in young adults (≥18 to 24 years), 242 (66.1%) in middle-aged adults (≥24 to 55 years), 58 (15.8%) in older adults (≥55 to 75 years), and 10 (2.7%) in older old adults (...) in middle-aged adults. No significant difference was found between older adults (g = 0.66; 95% CI, 0.51-0.82) and those in older old adults (g = 0.97; 95% CI, 0.42-1.52). The outcomes should be considered with caution because of the suboptimal quality of most of the studies and the high levels of heterogeneity. However, most primary findings proved robust across sensitivity analyses, addressing risk of bias, target populations included, type of therapy, diagnosis of mood disorder, and method of data

2020 EvidenceUpdates

48. Conservative vs Surgical Treatment of Impacted Femoral Neck Fracture in Patients 75 Years and Older

Copy Actions Cite Share Permalink Copy Page navigation J Am Geriatr Soc Actions . 2020 May 15. doi: 10.1111/jgs.16535. Online ahead of print. Conservative vs Surgical Treatment of Impacted Femoral Neck Fracture in Patients 75 Years and Older , , , , , Affiliations Expand Affiliation 1 Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. PMID: 32413174 DOI: Item in Clipboard Conservative vs Surgical Treatment of Impacted Femoral Neck Fracture in Patients 75 (...) Years and Older Peiran Wei et al. J Am Geriatr Soc . 2020 . Show details J Am Geriatr Soc Actions . 2020 May 15. doi: 10.1111/jgs.16535. Online ahead of print. Authors , , , , , Affiliation 1 Department of Orthopaedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, China. PMID: 32413174 DOI: Item in Clipboard Full-text links Cite Abstract Objective: To evaluate the safety and effectiveness of conservative treatment (CST), internal fixation (IF), and hemiarthroplasty (HA) in treating

2020 EvidenceUpdates

49. Dementia and mild cognitive impairment in prisoners aged over 50 years in England and Wales: a mixed-methods study Full Text available with Trip Pro

Dementia and mild cognitive impairment in prisoners aged over 50 years in England and Wales: a mixed-methods study Dementia and mild cognitive impairment in prisoners aged over 50 years in England and Wales: a mixed-methods study Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find (...) the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1)"> {{metadata.Title}} {{metadata.Headline}} This study found a relatively high prevalence of dementia/mild cognitive impairment in prisons and it developed a care pathway and training materials for staff and prisoners. {{author}} {{($index , , , , , , , , , , , , , , , , , , , , , , & . Katrina Forsyth 1 , Leanne Heathcote 1 , Jane Senior 1, * , Baber Malik 1 , Rachel Meacock 1 , Katherine Perryman 1 , Sue Tucker 1 , Rachel

2020 NIHR HTA programme

50. Medication management in older people: the MEMORABLE realist synthesis Full Text available with Trip Pro

Medication management in older people: the MEMORABLE realist synthesis Medication management in older people: the MEMORABLE realist synthesis Journals Library An error occurred retrieving content to display, please try again. >> >> >> Page Not Found Page not found (404) Sorry - the page you requested could not be found. Please choose a page from the navigation or try a website search above to find the information you need. >> >> >> >> Issue {{metadata .Issue }} Toolkit 1)"> 0)"> 1

2020 NIHR HTA programme

51. Ivacaftor (combination with ivacaftor/tezacaftor, cystic fibrosis, 12 years and older, with F508del mutation, heterozygous) - Benefit assessment according to §35a Social Code Book V

report is the assessment of the added benefit of ivacaftor in combination with tezacaftor/ivacaftor in comparison with the appropriate comparator therapy (ACT) best supportive care (BSC) in patients with cystic fibrosis (CF) aged 12 years and older who are heterozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The patients have one of the following mutations on the second allele: P67L, R117C, L206W, R352Q, A455E, D579G, 711+3A?G, S945L, S977F (...) , R1070W, D1152H, 2789+5G?A, 3272-26A?G and 3849+10kbC?T. Table 2: Research questions of the benefit assessment of ivacaftor + tezacaftor/ivacaftor + BSC Therapeutic indication ACT a Patients with cystic fibrosis aged 12 years and older who are heterozygous for the F508del mutation and have one of the following 14 mutations on the second allele in the CFTR gene b : P67L, R117C, L206W, R352Q, A455E, D579G, 711+3A?G, S945L, S977F, R1070W, D1152H, 2789+5G?A, 3272-26A?G and 3849+10kbC?T BSC a: Presentation

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

52. Ivacaftor (combination with ivacaftor/tezacaftor, cystic fibrosis, 12 years and older, with F508del mutation, homozygous) - Benefit assessment according to §35a Social Code Book V

benefit of ivacaftor in combination with tezacaftor/ivacaftor in comparison with the appropriate comparator therapy (ACT) lumacaftor/ivacaftor in patients with cystic fibrosis (CF) aged 12 years and older who are homozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Table 2: Research question of the benefit assessment of ivacaftor + tezacaftor/ivacaftor Therapeutic indication ACT a CF patients aged 12 years and older who are homozygous (...) + tezacaftor/ivacaftor) The VX14-661-106 study was a randomized, double-blind, parallel-group study, in which patients were treated with ivacaftor + tezacaftor/ivacaftor or received matching placebo, each against the background of concomitant symptomatic treatment. The study included patients aged 12 years and older who were homozygous for the F508del mutation in the CFTR gene and who had confirmed diagnosis of CF defined as a sweat chloride value of = 60 mmol/L. In addition, the patients had to have

2020 Institute for Quality and Efficiency in Healthcare (IQWiG)

53. Old and New Geriatric Screening Tools in a Belgian Emergency Department: A Diagnostic Accuracy Study

Old and New Geriatric Screening Tools in a Belgian Emergency Department: A Diagnostic Accuracy Study Old and New Geriatric Screening Tools in a Belgian Emergency Department: A Diagnostic Accuracy Study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center (...) Copy Actions Cite Share Permalink Copy Page navigation J Am Geriatr Soc Actions . 2020 Jul;68(7):1454-1461. doi: 10.1111/jgs.16503. Epub 2020 May 13. Old and New Geriatric Screening Tools in a Belgian Emergency Department: A Diagnostic Accuracy Study , , , , , , Affiliations Expand Affiliations 1 Department of Public Health and Primary Care, Academic Centre for Nursing and Midwifery, KU Leuven, Leuven, Belgium. 2 Department of Geriatric Medicine, University Hospitals Leuven, Leuven, Belgium. 3

2020 EvidenceUpdates

54. Prevention of adverse drug reactions in hospitalized older patients with multi-morbidity and polypharmacy: the SENATOR* randomized controlled clinical trial Full Text available with Trip Pro

; adverse drug reactions; multi-morbidity; older people; polypharmacy; prevention; software. © The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com. Similar articles Lavan AH, O'Mahony D, Gallagher P, Fordham R, Flanagan E, Dahly D, Byrne S, Petrovic M, Gudmundsson A, Samuelsson O, Cherubini A, J Cruz-Jentoft A, Soiza RL, Eustace JA. Lavan AH, et al. BMC Geriatr. 2019 Feb (...) Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Age Ageing Actions . 2020 Jul 1;49(4):605-614. doi: 10.1093/ageing/afaa072. Prevention of adverse drug reactions in hospitalized older patients with multi-morbidity and polypharmacy: the SENATOR* randomized controlled clinical trial , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , Affiliations Expand Affiliations 1 University

2020 EvidenceUpdates

55. Comparative Reactogenicity of Enhanced Influenza Vaccines in Older Adults

Comparative Reactogenicity of Enhanced Influenza Vaccines in Older Adults Comparative Reactogenicity of Enhanced Influenza Vaccines in Older Adults - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health National Library of Medicine National Center for Biotechnology Information Show account info Close Account (...) navigation J Infect Dis Actions . 2020 May 14;jiaa255. doi: 10.1093/infdis/jiaa255. Online ahead of print. Comparative Reactogenicity of Enhanced Influenza Vaccines in Older Adults , , , , , , , , , Affiliations Expand Affiliations 1 World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China. 2 Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA

2020 EvidenceUpdates

56. Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients

and need to accept minimally invasive analgesia. Objectives: This study aimed to investigate the effects of spinal cord stimulation (SCS) and pulsed radiofrequency (PRF) on the treatment of elderly patients with HZ-related pain persisting beyond the acute phase. Study design: A prospective, randomized-controlled trial. Setting: Research was conducted at the National Pain Management and Research Center, China-Japan Friendship Hospital (Beijing, China). Methods: We selected 63 patients aged over 50 years (...) Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients Clinical Study of Spinal Cord Stimulation and Pulsed Radiofrequency for Management of Herpes Zoster-Related Pain Persisting Beyond Acute Phase in Elderly Patients - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other

2020 EvidenceUpdates

57. Frailty and associated prognosis among older emergency department patients with suspected infection: A prospective, observational cohort study

of ED presentation (aOR 2.05; 95% CI, 1.02-5.24). Sensitivity for mortality was highest among the CFS (73.1%; 95% CI, 52.2-88.4), compared with SIRS ≥ 2 (65.4%; 95% CI, 44.3-82.8) or qSOFA ≥ 2 (38.4; 95% CI, 20.2-59.4). Conclusions: Frailty is a highly prevalent prognostic factor that can be used to risk-stratify older ED patients with suspected infection. ED clinicians should consider screening for frailty to optimize disposition in this population. Keywords: Frailty; geriatrics; infection; sepsis (...) Frailty and associated prognosis among older emergency department patients with suspected infection: A prospective, observational cohort study Frailty and associated prognosis among older emergency department patients with suspected infection: A prospective, observational cohort study - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable

2020 EvidenceUpdates

58. Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain: A Preliminary Randomized Comparison Trial

Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain: A Preliminary Randomized Comparison Trial Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain: A Preliminary Randomized Comparison Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage (...) Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation Pain Med Actions . 2020 May 25;pnaa145. doi: 10.1093/pm/pnaa145. Online ahead of print. Emotional Awareness and Expression Therapy Achieves Greater Pain Reduction than Cognitive Behavioral Therapy in Older Adults with Chronic Musculoskeletal Pain

2020 EvidenceUpdates

59. Therapeutic Effects of Exercise Training on Elderly Patients With Dementia: A Randomized Controlled Trial

, Taichung Veterans General Hospital, Taichung, Taiwan. 3 Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan. 4 Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan. 5 Department (...) of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. 6 Department of Physical Medicine and Rehabilitation, Taichung Veterans General Hospital, Taichung, Taiwan; Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address: rifampin@gmail.com. PMID: 32084347 DOI: Item in Clipboard

2020 EvidenceUpdates

60. Impact of macronutrient supplements on later growth of children born preterm or small for gestational age: A systematic review and meta-analysis of randomised and quasirandomised controlled trials Full Text available with Trip Pro

Impact of macronutrient supplements on later growth of children born preterm or small for gestational age: A systematic review and meta-analysis of randomised and quasirandomised controlled trials Impact of macronutrient supplements on later growth of children born preterm or small for gestational age: A systematic review and meta-analysis of randomised and quasirandomised controlled trials - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete (...) Optional text in email: Save Cancel Create a file for external citation management software Create file Cancel Your RSS Feed Name of RSS Feed: Number of items displayed: Create RSS Cancel RSS Link Copy Actions Cite Share Permalink Copy Page navigation PLoS Med Actions . 2020 May 26;17(5):e1003122. doi: 10.1371/journal.pmed.1003122. eCollection 2020 May. Impact of macronutrient supplements on later growth of children born preterm or small for gestational age: A systematic review and meta-analysis

2020 EvidenceUpdates