Latest & greatest articles for geriatrics

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Top results for geriatrics

4601. Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children. (Abstract)

Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children. Oral vaccines offer great promise as public-health measures to prevent disease in less-developed countries. CVD 103-HgR, a genetically engineered, attenuated, Vibrio cholerae O1 strain has proved effective in industrialised countries. We have assessed the safety, immunogenicity, and excretion of this live cholera vaccine in children in north Jakarta, Indonesia. 412 children aged 5

1992 Lancet Controlled trial quality: uncertain

4602. Randomised trial of case finding and surveillance of elderly people at home. (Abstract)

Randomised trial of case finding and surveillance of elderly people at home. Health screening for old people who live at home has been the subject of debate for 30 years or so. It has come to the fore again in the UK with the new emphasis on annual assessments by general practitioners (GPs) of those aged 75 or more. Screening in the elderly has implications for manpower. How can it best be done? We describe here a randomised, controlled study of case finding and surveillance in patients aged 65 (...) visits by a GP. Quality-of-life measures revealed no between-group differences, but self-rated health status was superior in the intervention group. We conclude that the use of a postal screening questionnaire with selective follow-up and intervention can favourably influence outcome and use of health care resources by elderly people living at home.

1992 Lancet Controlled trial quality: uncertain

4603. Comparison of umbilical-artery velocimetry and cardiotocography for surveillance of small-for-gestational-age fetuses. (Abstract)

Comparison of umbilical-artery velocimetry and cardiotocography for surveillance of small-for-gestational-age fetuses. Intrauterine growth retardation is associated with an increased risk of fetal asphyxia as well as greater perinatal morbidity and mortality. Ultrasound fetometry enables detection of fetuses that are small for gestational age. Doppler velocimetry of the umbilical artery has good predictive ability for fetal distress, but it is not yet clear whether it could replace (...) cardiotocography in antenatal surveillance of small-for-gestational-age fetuses. We have done a randomised comparison of the two methods. At four obstetric departments in Sweden, women with fetuses found to be small on ultrasound examination at 31 completed weeks of pregnancy or later were randomly assigned to antenatal surveillance with either doppler velocimetry (doppler; 214) or cardiotocography (CTG; 212). Pregnancies in the doppler group were managed according to a protocol based on blood-flow classes

1992 Lancet Controlled trial quality: uncertain

4604. Can health visitors prevent fractures in elderly people? Full Text available with Trip Pro

Can health visitors prevent fractures in elderly people? To assess whether intervention by a health visitor could reduce the number of fractures, over a four year period, in those aged 70 and over.Randomised, controlled trial; randomisation by household.General practice in a market town.Of 863 patients aged 70 and over on the practice records, 674 were traced and successfully interviewed; 350 were assigned to the intervention group, 324 as controls.The people in the intervention group were (...) over four years.The incidence of fractures was 5% (16/350) in the intervention group and 4% (14/324) in the control group (difference not significant).A health visitor visiting a group of people aged 70 and over and using simple preventive measures had no effect on the incidence of fractures.

1992 BMJ Controlled trial quality: uncertain

4605. Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. (Abstract)

Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects. Ageing is associated with impaired immune responses and increased infection-related morbidity. This study assessed the effect of physiological amounts of vitamins and trace elements on immunocompetence and occurrence of infection-related illness. 96 independently living, healthy elderly individuals were randomly assigned to receive nutrient supplementation or placebo. Nutrient status (...) year, p = 0.002). Supplementation with a modest physiological amount of micronutrients improves immunity and decreases the risk of infection in old age.

1992 Lancet Controlled trial quality: uncertain

4606. Effect of regular exercise on 24-hour arterial pressure in older hypertensive humans. (Abstract)

Effect of regular exercise on 24-hour arterial pressure in older hypertensive humans. The experimental goals were to determine if regular low-intensity aerobic exercise reduces 24-hour arterial blood pressure in middle-aged and older (aged 50 years or older) humans with mild diastolic (90-105 mm Hg) essential hypertension and, if so, whether this is accurately reflected by changes in casual recordings made at rest. Fourteen subjects walked 3-4 days/wk for 6 months, with 10 exercising (...) -aged and older humans with mild (diastolic) essential hypertension and 2) training-associated changes in casually determined blood pressure at rest are dependent on the measurement conditions and, most importantly, do not necessarily reflect the magnitude or even the direction of changes in arterial pressure throughout an entire day.

1991 Hypertension (Dallas, Tex. : 1979)

4607. Systolic Hypertension in the Elderly Program (SHEP). Part 8: Electrocardiographic characteristics. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 8: Electrocardiographic characteristics. 1825649 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 8: Electrocardiographic characteristics. II123-51 Kostis J B JB Prineas R R Curb J D JD Lee M M Berkson D D Raines J J Frishman W W Francis C K CK Sheffield T T eng Clinical Trial Journal Article Multicenter Study Randomized (...) Controlled Trial United States Hypertension 7906255 0194-911X IM African Continental Ancestry Group Aged Aged, 80 and over Cardiomegaly Cohort Studies Electrocardiography European Continental Ancestry Group Female Heart Rate Humans Hypertension diagnosis Male Middle Aged Systole 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1825649

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4608. Systolic Hypertension of the Elderly Program (SHEP). Part 9: Behavioral characteristics. (Abstract)

Systolic Hypertension of the Elderly Program (SHEP). Part 9: Behavioral characteristics. 1999370 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension of the Elderly Program (SHEP). Part 9: Behavioral characteristics. II152-61 Weiler P G PG Camel G H GH Chiappini M M Greenlick M R MR Hughes G H GH Luhr J C JC Moyé L A LA Mungas D D Perron M M Peters M H MH eng Clinical Trial Journal Article Randomized Controlled Trial United (...) States Hypertension 7906255 0194-911X IM Behavior Depression Female Humans Hypertension therapy Male Middle Aged Neuropsychological Tests Quality of Life Surveys and Questionnaires Systole 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999370

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4609. Systolic Hypertension in the Elderly Program (SHEP). Part 2: Screening and recruitment. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 2: Screening and recruitment. 1999371 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 2: Screening and recruitment. II16-23 Petrovitch H H Byington R R Bailey G G Borhani P P Carmody S S Goodwin L L Harrington J J Johnson H A HA Johnson P P Jones M M eng Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial (...) United States Hypertension 7906255 0194-911X IM Decision Making Health Services Needs and Demand Health Services for the Aged Humans Hypertension epidemiology therapy Mass Screening Research Design Systole United States epidemiology 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999371

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4610. Systolic Hypertension in the Elderly Program (SHEP). Part 1: Rationale and design. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 1: Rationale and design. 1999373 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 1: Rationale and design. II2-15 Borhani N O NO Applegate W B WB Cutler J A JA Davis B R BR Furberg C D CD Lakatos E E Page L L Perry H M HM Smith W M WM Probstfield J L JL eng Clinical Trial Journal Article Multicenter Study Randomized Controlled (...) Trial United States Hypertension 7906255 0194-911X IM Health Policy Health Services for the Aged Humans Hypertension epidemiology mortality therapy Nutrition Surveys Research Design Systole United States epidemiology 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999373

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4611. Systolic Hypertension in the Elderly Program (SHEP). Part 7: Baseline laboratory characteristics. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 7: Baseline laboratory characteristics. 1999369 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 7: Baseline laboratory characteristics. II102-22 Hall W D WD Davis B R BR Frost P P Hoffmeier M M O'Brien J E JE Pace S S Page L L Schneider K A KA Stamler J J eng Clinical Trial Journal Article Multicenter Study Randomized Controlled (...) Trial United States Hypertension 7906255 0194-911X 0 Blood Glucose 0 Enzymes 0 Lipids 0 Minerals 268B43MJ25 Uric Acid IM African Continental Ancestry Group Aged Aged, 80 and over Blood Chemical Analysis Blood Glucose metabolism Enzymes blood European Continental Ancestry Group Female Humans Hypertension diagnosis epidemiology Lipids blood Male Middle Aged Minerals blood Quality Control Systole Uric Acid blood 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999369

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4612. Systolic Hypertension in the Elderly Program (SHEP). Part 3: Sociodemographic characteristics. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 3: Sociodemographic characteristics. 1999374 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 3: Sociodemographic characteristics. II24-34 Vogt T M TM Schron E E Pressel S S Wasserthiel-Smoller S S Eddleman E E EE Miller S S Stamler J J eng Clinical Trial Journal Article Multicenter Study Randomized Controlled Trial United States (...) Hypertension 7906255 0194-911X IM Cohort Studies Demography Health Services for the Aged Humans Hypertension therapy Research Design Socioeconomic Factors Systole United States epidemiology 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999374

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4613. Systolic Hypertension in the Elderly Program (SHEP). Part 4: Baseline medical history findings. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 4: Baseline medical history findings. 1999375 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 4: Baseline medical history findings. II35-61 Curb J D JD Lee M M Jensen J J Applegate W W eng Clinical Trial Journal Article Randomized Controlled Trial United States Hypertension 7906255 0194-911X IM Health Services for the Aged Humans

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4614. Systolic Hypertension in the Elderly Program (SHEP). Part 5: Baseline blood pressure and pulse rate measurements. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 5: Baseline blood pressure and pulse rate measurements. 1999376 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 5: Baseline blood pressure and pulse rate measurements. II62-76 Labarthe D R DR Blaufox M D MD Smith W M WM Lacy C R CR Schnaper H H LaBaw F F Mascioli S S Davey J J Lakatos E E eng Clinical Trial Journal Article (...) Multicenter Study Randomized Controlled Trial United States Hypertension 7906255 0194-911X IM African Continental Ancestry Group Aged Aged, 80 and over Blood Pressure European Continental Ancestry Group Female Humans Hypertension therapy Male Middle Aged Pulse Systole 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999376

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4615. Systolic Hypertension in the Elderly Program (SHEP). Part 6: Baseline physical examination findings. (Abstract)

Systolic Hypertension in the Elderly Program (SHEP). Part 6: Baseline physical examination findings. 1999377 1991 04 09 2016 07 26 0194-911X 17 3 Suppl 1991 Mar Hypertension (Dallas, Tex. : 1979) Hypertension Systolic Hypertension in the Elderly Program (SHEP). Part 6: Baseline physical examination findings. II77-101 Black H R HR Unger D D Burlando A A Wright J C JC Pressel S L SL Allen R R McDonald R H RH Surath H H eng Clinical Trial Journal Article Multicenter Study Randomized Controlled (...) Trial United States Hypertension 7906255 0194-911X IM African Continental Ancestry Group Aged Aged, 80 and over Anthropometry European Continental Ancestry Group Female Humans Hypertension therapy Male Middle Aged Physical Examination Systole 1991 3 1 1991 3 1 0 1 1991 3 1 0 0 ppublish 1999377

1991 Hypertension (Dallas, Tex. : 1979) Controlled trial quality: uncertain

4616. Efficacy of bladder training in older women with urinary incontinence. (Abstract)

Efficacy of bladder training in older women with urinary incontinence. The efficacy of bladder training was evaluated in a randomized clinical trial involving 123 noninstitutionalized women 55 years and older with urinary incontinence. Subjects were urodynamically categorized as those with urethral sphincteric incompetence (N = 88) and those with detrusor instability with or without concomitant sphincteric incompetence (N = 35). Bladder training reduced the number of incontinent episodes by 57

1991 JAMA Controlled trial quality: uncertain

4617. Role of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients. (Abstract)

Role of candida in pathogenesis of antibiotic-associated diarrhoea in elderly inpatients. The part that candida plays in antibiotic-associated diarrhoea was investigated in 24 elderly inpatients (mean age 74 years) who tested negative for Clostridium difficile toxin and other intestinal pathogens. 7 had intestinal overgrowth of Candida species (greater than or equal to 10(5) cfu/ml). None of the 24 matched, antibiotic-treated controls without diarrhoea had candida overgrowth. All 5 patients

1991 Lancet

4618. Terodiline with bladder retraining for treating detrusor instability in elderly people. Full Text available with Trip Pro

Terodiline with bladder retraining for treating detrusor instability in elderly people. To compare terodiline with bladder retraining against placebo with bladder retraining in the treatment of detrusor instability in frail elderly patients.Randomised, double blind, parallel group study. Treatment lasted for six weeks. Frequency of micturition and episodes of incontinence recorded on diary chart by patients.Incontinence clinic and a geriatric day hospital at two teaching hospitals.37 frail (...) but ambulant patients, mean (range) age 80.4 (70-89) years with urinary frequency and urge incontinence, due to detrusor instability. Two patients withdrew before the first assessment (one in each group) and one could not complete the diary chart (placebo group).19 patients received bladder retraining and terodiline 25 mg daily and 18 bladder retraining and placebo.Change in urinary frequency and number of episodes of incontinence after six weeks' treatment. Patient's subjective evaluation

1991 BMJ Controlled trial quality: predicted high

4619. Sensitivity to triazolam in the elderly. (Abstract)

Sensitivity to triazolam in the elderly. Elderly persons frequently appear to be sensitive to the effects of many drugs that depress the central nervous system. We studied the effect of age on the pharmacokinetics and pharmacodynamics of the benzodiazepine hypnotic agent triazolam, now the most frequently prescribed hypnotic drug in the United States.Twenty-six healthy young subjects (mean age, 30 years) and 21 healthy elderly subjects (mean age, 69 years) participated in a four-way crossover (...) study. After a single-blind adaptation trial with placebo, each subject received, in random order and in double-blind fashion, single doses of placebo, 0.125 mg of triazolam, and 0.25 mg of triazolam. For 24 hours after the administration of each of the three study medications, plasma triazolam levels were determined and psychomotor performance, memory, and degree of sedation were assessed.Plasma triazolam concentrations increased in proportion to the dose, but the elderly subjects had higher plasma

1991 NEJM Controlled trial quality: uncertain

4620. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. (Abstract)

Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. To assess the ability of antihypertensive drug treatment to reduce the risk of nonfatal and fatal (total) stroke in isolated systolic hypertension.Multicenter, randomized, double-blind, placebo-controlled.Community-based ambulatory population in tertiary care centers.4736 persons (...) (1.06%) from 447,921 screenees aged 60 years and above were randomized (2365 to active treatment, 2371 to placebo). Systolic blood pressure ranged from 160 to 219 mm Hg and diastolic blood pressure was less than 90 mm Hg. Of the participants, 3161 were not receiving antihypertensive medication at initial contact, and 1575 were. The average systolic blood pressure was 170 mm Hg; average diastolic blood pressure, 77 mm Hg. The mean age was 72 years, 57% were women, and 14% were black.--Participants

1991 JAMA Controlled trial quality: predicted high