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Cardiovasculardisease prevention: applying All Our Health Cardiovasculardisease prevention: applying All Our Health - GOV.UK Tell us whether you accept cookies We use about how you use GOV.UK. We use this information to make the website work as well as possible and improve government services. Accept all cookies You’ve accepted all cookies. You can at any time. Hide Search Guidance Cardiovasculardisease prevention: applying All Our Health Evidence and guidance to help healthcare (...) January 2019 Last updated 16 December 2019 16 December 2019 Added link to the NHS Health Check best practice guidance. 17 June 2019 Added link to cardiovasculardisease prevention e-learning resource. 9 January 2019 First published. Related content Collection Explore the topic Is this page useful? Thank you for your feedback Help us improve GOV.UK Don’t include personal or financial information like your National Insurance number or credit card details. What were you doing? What went wrong? Send Help
The role of community-based nursing interventions in improving outcomes for individuals with cardiovasculardisease: A systematic review To examine the role of community-based nursing interventions in improving outcomes for community-dwelling individuals with cardiovascular disease.A systematic review and narrative synthesis.Seven electronic databases (MEDLINE, CINAHL, Global Health, LILACS, Africa-Wide Information, IMEMR and WPRIM) were searched from inception to 16 March 2018 without language (...) restrictions.We included studies evaluating the outcomes of interventions led by, or primarily delivered by, nurses for individuals with cardiovasculardisease in community settings. Study selection, data extraction and risk of bias assessments were performed by at least two independent reviewers.Twenty-eight studies met the inclusion criteria and were included in this review. Community-based nursing interventions improved outcomes in four key areas: (1) self-care, (2) health, (3) healthcare utilisation
A systematic review of community nursing interventions focusing on improving outcomes for individuals exhibiting risk factors of cardiovasculardisease To examine the role of community-based nursing interventions in improving outcomes for community-dwelling individuals exhibiting risk factors of cardiovasculardisease (CVD).A systematic review and narrative synthesis.Seven electronic databases (MEDLINE, CINAHL, Global Health, LILACS, Africa-Wide Information, IMEMR, and WPRIM) were searched from
Comparison of Frequency of Atherosclerotic CardiovascularDisease Events Among Primary and Secondary Prevention Subgroups of the Systolic Blood Pressure Intervention Trial The Pooled Cohort Equation (PCE) predicts 10-year risk of first-time atherosclerotic cardiovasculardisease (ASCVD) events and was incorporated in analyses of a primary and secondary prevention population in the Systolic Blood Pressure Intervention Trial (SPRINT). Whether PCE enhances risk prediction among secondary
Estimating individual lifetime benefit and bleeding risk of adding rivaroxaban to aspirin for patients with stable cardiovasculardisease: results from the COMPASS trial Adding rivaroxaban to aspirin in patients with stable atherosclerotic disease reduces the recurrence of cardiovasculardisease (CVD) but increases the risk of major bleeding. The aim of this study was to estimate the individual lifetime treatment benefit and harm of adding low-dose rivaroxaban to aspirin in patients with stable (...) cardiovascular disease.Patients with established CVD from the COMPASS trial (n = 27 390) and SMART prospective cohort study (n = 8139) were used. Using the pre-existing lifetime SMART-REACH model for recurrent CVD, and a newly developed Fine and Gray competing risk-adjusted lifetime model for major bleeding, individual treatment effects from adding low-dose rivaroxaban to aspirin in patients with stable CVD were estimated, expressed in terms of (i) life-years free of stroke or myocardial infarction (MI
Mothers of Infants with Heart Defects and Increased Long-Term Risk of CardiovascularDisease "Mothers of Infants with Heart Defects and Increased Long-Term Risk of " by Anne Crowl < > > > > > Title Author Date of Graduation Summer 8-10-2019 Degree Type Capstone Project Degree Name Master of Science in Physician Assistant Studies Rights . Abstract Background: Cardiovasculardisease (CVD) is responsible for approximately 1 in every 3 deaths of women in the United States. Recognizing the symptoms (...) are at an increased risk for CVD. Additional research would determine if the risk further increased in post-menopausal women who are already at a higher risk of developing CVD. Recommended Citation Crowl, Anne, "Mothers of Infants with Heart Defects and Increased Long-Term Risk of CardiovascularDisease" (2019). School of Physician Assistant Studies . 680. https://commons.pacificu.edu/pa/680 DOWNLOADS Since August 02, 2019 Included in Share COinS Browse Search Enter search terms: Select context to search: Authors
Medium and long-term risks of specific cardiovasculardiseases in survivors of 20 adult cancers: a population-based cohort study using multiple linked UK electronic health records databases. The past few decades have seen substantial improvements in cancer survival, but concerns exist about long-term cardiovasculardisease risk in survivors. Evidence is scarce on the risks of specific cardiovasculardiseases in survivors of a wide range of cancers to inform prevention and management (...) for a range of cardiovasculardisease outcomes using crude and adjusted Cox models. We fitted interactions to investigate effect modification, and flexible parametric survival models to estimate absolute excess risks over time.Between Jan 1, 1990, and Dec 31, 2015, 126 120 individuals with a diagnosis of a cancer of interest still being followed up at least 1 year later were identified and matched to 630 144 controls. After exclusions, 108 215 cancer survivors and 523 541 controls were included
Polypill for CardiovascularDisease Prevention in an Underserved Population. Persons with low socioeconomic status and nonwhite persons in the United States have high rates of cardiovasculardisease. The use of combination pills (also called "polypills") containing low doses of medications with proven benefits for the prevention of cardiovasculardisease may be beneficial in such persons. However, few data are available regarding the use of polypill therapy in underserved communities (...) in the United States, in which adherence to guideline-based care is generally low.We conducted a randomized, controlled trial involving adults without cardiovasculardisease. Participants were assigned to the polypill group or the usual-care group at a federally qualified community health center in Alabama. Components of the polypill were atorvastatin (at a dose of 10 mg), amlodipine (2.5 mg), losartan (25 mg), and hydrochlorothiazide (12.5 mg). The two primary outcomes were the changes from baseline
Modifiable risk factors, cardiovasculardisease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. Global estimates of the effect of common modifiable risk factors on cardiovasculardisease and mortality are largely based on data from separate studies, using different methodologies. The Prospective Urban Rural Epidemiology (PURE) study overcomes these limitations by using similar methods to prospectively measure (...) the effect of modifiable risk factors on cardiovasculardisease and mortality across 21 countries (spanning five continents) grouped by different economic levels.In this multinational, prospective cohort study, we examined associations for 14 potentially modifiable risk factors with mortality and cardiovasculardisease in 155 722 participants without a prior history of cardiovasculardisease from 21 high-income, middle-income, or low-income countries (HICs, MICs, or LICs). The primary outcomes
Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of CardiovascularDisease. The relationship between exposure to lower low-density lipoprotein cholesterol (LDL-C) and lower systolic blood pressure (SBP) with the risk of cardiovasculardisease has not been reliably quantified.To assess the association of lifetime exposure to the combination of both lower LDL-C and lower SBP with the lifetime risk (...) of cardiovascular disease.Among 438 952 participants enrolled in the UK Biobank between 2006 and 2010 and followed up through 2018, genetic LDL-C and SBP scores were used as instruments to divide participants into groups with lifetime exposure to lower LDL-C, lower SBP, or both. Differences in plasma LDL-C, SBP, and cardiovascular event rates between the groups were compared to estimate associations with lifetime risk of cardiovascular disease.Differences in plasma LDL-C and SBP compared with participants
Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovasculardisease (primary prevention).In CREDENCE (Canagliflozin and Renal Events in Diabetes (...) ]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome).Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease.URL: https
Effects of Liraglutide Compared With Placebo on Events of Acute Gallbladder or Biliary Disease in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events in the LEADER Randomized Trial To explore gallbladder- and biliary tract-related events reported for the liraglutide and placebo groups in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial.LEADER was an international, randomized, double-blind, controlled cardiovascular (CV (...) ) outcomes trial. Participants with type 2 diabetes at high risk for CV events (n = 9,340) were randomized 1:1 to receive either liraglutide (≤1.8 mg daily; n = 4,668) or placebo (n = 4,672), with both groups also receiving standard care (treatment period: 3.5-5 years). Acute gallstone disease was a medical event of special interest. This post hoc analysis categorized captured events of acute gallbladder or biliary disease into four groups: uncomplicated gallbladder stones, complicated gallbladder stones
A Meta-analysis of Aspirin for the Primary Prevention of CardiovascularDiseases in the Context of Contemporary Preventive Strategies The role of aspirin for primary prevention of cardiovasculardiseases remains controversial, particularly in the context of contemporary aggressive preventive strategies.Relevant randomized clinical trials were included, and risk ratios (RRs) were calculated using random-effects models. Additional moderator analyses were performed to compare the pooled treatment (...) . Differences between aspirin and placebo in the risks for all-cause stroke, cardiac death, and all-cause mortality were not found.In the context of contemporary primary prevention guidelines, the effect of aspirin on myocardial infarction risk was significantly attenuated, whereas its major bleeding and hemorrhagic stroke complications were retained. Therefore, in contemporary practice, routine use of aspirin for the primary prevention of cardiovascular events may have a net harmful effect.Published
Eligibility and subsequent burden of cardiovasculardisease of four strategies for blood pressure-lowering treatment: a retrospective cohort study. Worldwide treatment recommendations for lowering blood pressure continue to be guided predominantly by blood pressure thresholds, despite strong evidence that the benefits of blood pressure reduction are observed in patients across the blood pressure spectrum. In this study, we aimed to investigate the implications of alternative strategies (...) for offering blood pressure treatment, using the UK as an illustrative example.We did a retrospective cohort study in primary care patients aged 30-79 years without cardiovasculardisease, using data from the UK's Clinical Practice Research Datalink linked to Hospital Episode Statistics and Office for National Statistics mortality. We assessed and compared four different strategies to determine eligibility for treatment: using 2011 UK National Institute for Health and Care Excellence (NICE) guideline
Effectiveness of polypill for primary and secondary prevention of cardiovasculardiseases (PolyIran): a pragmatic, cluster-randomised trial. A fixed-dose combination therapy (polypill strategy) has been proposed as an approach to reduce the burden of cardiovasculardisease, especially in low-income and middle-income countries (LMICs). The PolyIran study aimed to assess the effectiveness and safety of a four-component polypill including aspirin, atorvastatin, hydrochlorothiazide, and either (...) participants in the minimal care group. Median adherence to polypill tablets was 80·5% (IQR 48·5-92·2). During follow-up, 301 (8·8%) of 3417 participants in the minimal care group had major cardiovascular events compared with 202 (5·9%) of 3421 participants in the polypill group (adjusted hazard ratio [HR] 0·66, 95% CI 0·55-0·80). We found no statistically significant interaction with the presence (HR 0·61, 95% CI 0·49-0·75) or absence of pre-existing cardiovasculardisease (0·80; 0·51-1·12; pinteraction=0
2019LancetControlled trial quality: predicted high
Association of Smoking Cessation With Subsequent Risk of CardiovascularDisease. The time course of cardiovasculardisease (CVD) risk after smoking cessation is unclear. Risk calculators consider former smokers to be at risk for only 5 years.To evaluate the association between years since quitting smoking and incident CVD.Retrospective analysis of prospectively collected data from Framingham Heart Study participants without baseline CVD (original cohort: attending their fourth examination (...) in 1954-1958; offspring cohort: attending their first examination in 1971-1975) who were followed up through December 2015.Time-updated self-reported smoking status, years since quitting, and cumulative pack-years.Incident CVD (myocardial infarction, stroke, heart failure, or cardiovascular death). Primary analyses included both cohorts (pooled) and were restricted to heavy ever smokers (≥20 pack-years).The study population included 8770 individuals (original cohort: n = 3805; offspring cohort: n