Latest & greatest articles for bronchiolitis

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Bronchiolitis

Bronchiolitis is mainly caused by the respiratory syncytial virus (RSV). The virus travels down to the bronchioles in the lungs causing them to become inflamed making it difficult to breath.

Almost every child will be infected with RSV by the time they reach two years. Adults can also contract the virus, typically during winter months.

In mild cases bronchiolitis will clear up without treatment. The virus that causes bronchiolitis travels through tiny droplets of liquid and can be passed through the air or contracted by touching infected surfaces.

Symptoms include: Sore throat, dry cough, blocked nose and aches and pains throughout the body.

Although there is no cure for chronic bronchiolitis research and clinical studies on bronchiolitis suggest that some lifestyle changes can ease symptoms: avoid smoking, eat a healthy diet and maintain regular exercise. In extreme cases steroids can be prescribed to help minimise inflammation.

Read more on medications used to treat bronchiolitis and the causes of the virus.

Top results for bronchiolitis

1. Continuous positive airway pressure (CPAP) for acute bronchiolitis in children. (PubMed)

Continuous positive airway pressure (CPAP) for acute bronchiolitis in children. Acute bronchiolitis is one of the most frequent causes of emergency department visits and hospitalisation in children. There is no specific treatment for bronchiolitis except for supportive treatment, which includes ensuring adequate hydration and oxygen supplementation. Continuous positive airway pressure (CPAP) aims to widen the lungs' peripheral airways, enabling deflation of overdistended lungs in bronchiolitis (...) . Increased airway pressure also prevents the collapse of poorly supported peripheral small airways during expiration. Observational studies report that CPAP is beneficial for children with acute bronchiolitis. This is an update of a review first published in 2015.To assess the efficacy and safety of CPAP compared to no CPAP or sham CPAP in infants and children up to three years of age with acute bronchiolitis.We conducted searches of CENTRAL (2017, Issue 12), which includes the Cochrane Acute Respiratory

2019 Cochrane

2. Bronchiolitis

Bronchiolitis Bronchiolitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis Last reviewed: February 2019 Last updated: January 2019 Summary Leading cause of hospital admission in infants under 1 year of age. Respiratory syncytial virus (RSV) is the most common cause. Most cases are mild and self-limiting, and supportive care is the only indicated therapy. Cough may persist for weeks, after 10 to 14 days (...) of acute illness. Some patients may go on to develop recurrent wheeze. Definition Viral bronchiolitis is an acute viral infection of the lower respiratory tract. Although it can affect individuals of any age, the term is most often used to refer to infection in infancy. It is characterised by epithelial cell destruction, cellular oedema, and airway obstruction by inflammatory debris and mucus. The clinical manifestations include cough, wheeze, and laboured breathing. Respiratory syncytial virus (RSV

2019 BMJ Best Practice

3. Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful

Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful Discover Portal Discover Portal Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful Published on 10 May 2016 doi: Chest physiotherapy for acute bronchiolitis in children under two has no benefits and may be harmful, according to a systematic review published by the Cochrane Collaboration. The research looked (...) at three different types of chest physiotherapy. It found that none of the techniques helped children with bronchiolitis recover more quickly or led to any improvement in their condition. Some types of chest physiotherapy may make breathing and blood-oxygen levels worse. This review’s findings suggest that chest physiotherapy should not normally be used for children hospitalised with severe bronchiolitis. The findings support current NICE guidance which says that children (who don’t have another

2019 NIHR Dissemination Centre

4. High-flow oxygen therapy may have a role in treating infants with more severe bronchiolitis

High-flow oxygen therapy may have a role in treating infants with more severe bronchiolitis High-flow oxygen therapy may have a role in treating infants with more severe bronchiolitis Discover Portal Discover Portal High-flow oxygen therapy may have a role in treating infants with more severe bronchiolitis Published on 18 September 2018 doi: A randomised controlled trial of 1,472 infants with bronchiolitis found that more children improved when started on high-flow oxygen therapy than (...) as first-line treatment or as "rescue" treatment in infants with bronchiolitis. Further research including cost-effectiveness will be needed before advocating high-flow oxygen for all infants hospitalised with bronchiolitis. Share your views on the research. Why was this study needed? Bronchiolitis is inflammation of small airways in the lungs. It is most commonly caused by respiratory syncytial virus, and usually affects infants. The first symptoms are similar to a cold, then cough, wheeze and fever

2019 NIHR Dissemination Centre

5. Systematic review of montelukast's efficacy and safety for the treatment of infantile bronchiolitis

Systematic review of montelukast's efficacy and safety for the treatment of infantile bronchiolitis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

6. Serum vitamin D levels in children with bronchiolitis: a systematic review and meta-analysis

Serum vitamin D levels in children with bronchiolitis: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external

2019 PROSPERO

7. Prolonged slow expiration technique improves recovery from acute bronchiolitis in infants: FIBARRIX randomized controlled trial

Prolonged slow expiration technique improves recovery from acute bronchiolitis in infants: FIBARRIX randomized controlled trial To examine the effect of prolonged slow expiration respiratory physiotherapy treatment on the acute bronchiolitis severity scale and O2 saturation at short-time and at medical discharge in infants and the hospital stay.Randomized controlled trial.Infants' unit of university hospital.Infants with acute bronchiolitis ( N = 80).Infants were randomized into respiratory (...) treatment (RT) with prolonged slow expiration or treatment as usual (control) for one-week period.The primary outcomes were Acute Bronchiolitis Severity Scale score and O2 saturation, recorded shortly after each intervention during the stay and at medical discharge, and the hospital stay.The RT had a significantly lower Acute Bronchiolitis Severity Scale 10-minute after the first intervention (mean difference -1.7 points, 95% confidence interval (CI) -3.0 to -0.38), 2 hours after (-2.0 points, 95% CI

2018 EvidenceUpdates

8. Less stringent target oxygen levels for acute bronchiolitis are safe and effective

Less stringent target oxygen levels for acute bronchiolitis are safe and effective Less stringent target oxygen levels for acute bronchiolitis are safe and effective Discover Portal Discover Portal Less stringent target oxygen levels for acute bronchiolitis are safe and effective Published on 1 December 2015 doi: This NIHR-funded trial found that acute bronchiolitis in children can be safely managed to a slightly lower target level of oxygen saturation than currently used. Setting the level (...) that this research may prompt a change in advice in due course. Share your views on the research. Why was this study needed? Bronchiolitis is a common respiratory tract infection affecting about 1 in 3 babies. About 2% to 3% of these babies develop severe breathing difficulties needing hospital treatment. The number of hospital admissions for bronchiolitis has been increasing over the last 10 years, from 21,330 admissions in England in 2004 to 30,451 in 2011. Children with bronchiolitis are treated

2018 NIHR Dissemination Centre

9. Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis

Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis Discover Portal Discover Portal Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis Published on 28 October 2015 doi: In this NIHR-funded trial babies with a viral chest infection (acute bronchiolitis) were treated either with a strong saline mist (nebulised 3% hypertonic sodium (...) hypertonic saline should not be used in these babies. Share your views on the research. Why was this study needed? Bronchiolitis is a common respiratory tract infection affecting about 1 in 3 babies. About 2% to 3% of these babies develop more severe symptoms, such as breathing difficulties, needing hospital treatment. The number of hospital admissions for bronchiolitis has been increasing over the last ten years, from 21,330 admissions in England in 2004 to 30,451 in 2011. A 2013 Cochrane systematic

2018 NIHR Dissemination Centre

10. Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD (PubMed)

Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD Chronic graft-versus-host disease (cGVHD) causes significant morbidity and mortality in patients after allogeneic bone marrow (BM) or stem cell transplantation (allo-SCT). Recent work has indicated that both T and B lymphocytes play an important role in the pathophysiology of cGVHD. Previously, our group showed a critical role for the germinal center response in the function of B cells using (...) a bronchiolitis obliterans (BO) model of cGVHD. Here, we demonstrated for the first time that cGVHD is associated with severe defects in the generation of BM B lymphoid and uncommitted common lymphoid progenitor cells. We found an increase in the number of donor CD4+ T cells in the BM of mice with cGVHD that was negatively correlated with B-cell development and the frequency of osteoblasts and Prrx-1-expressing perivascular stromal cells, which are present in the B-cell niche. Use of anti-DR3 monoclonal

Full Text available with Trip Pro

2018 Blood advances

11. Chronic Cough Related to Acute Viral Bronchiolitis in Children

Chronic Cough Related to Acute Viral Bronchiolitis in Children Chronic Cough Related to Acute Viral Bronchiolitis in Children CHEST Expert Panel Report Anne B. Chang, MBBS, PhD, MPH; John J. Oppenheimer, MD; Bruce K. Rubin, MD; Miles Weinberger, MD, FCCP; and Richard S. Irwin, MD, Master FCCP; on behalf of the CHEST Expert Cough Panel BACKGROUND: Acute bronchiolitis is common in young children, and some children develop chronic cough after their bronchiolitis. We thus undertook systematic (...) , no recommendations on using the interventions above could be formulated. CONCLUSIONS: The panel made several consensus-based suggestions and identi?ed directions for future studies to advance the ?eld of managing chronic cough post-acute bronchiolitis in children. CHEST 2018; 154(2):378-382 KEYWORDS: cough; evidence-based medicine; guidelines ABBREVIATIONS: KQ = key question; RCT = randomized controlled trial AFFILIATIONS: From the Division of Child Health (Dr Chang), MenziesSchoolofHealthResearch,Darwin

2018 American College of Chest Physicians

12. Bronchiolitis

Bronchiolitis Top results for bronchiolitis - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2 (...) ) and (#3 or #4) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for bronchiolitis The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms

2018 Trip Latest and Greatest

13. Bronchiolitis

Bronchiolitis Evidence Maps - Trip Database or use your Google+ account Turning Research Into Practice ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4

2018 Trip Evidence Maps

14. Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial

Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?

2018 PedsCCM Evidence-Based Journal Club

15. Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis

Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis Discover Portal Discover Portal Inhaling a saline mist did not reduce the time in hospital for babies with bronchiolitis Published on 28 October 2015 doi: In this NIHR-funded trial babies with a viral chest infection (acute bronchiolitis) were treated either with a strong saline mist (nebulised 3% hypertonic sodium (...) hypertonic saline should not be used in these babies. Share your views on the research. Why was this study needed? Bronchiolitis is a common respiratory tract infection affecting about 1 in 3 babies. About 2% to 3% of these babies develop more severe symptoms, such as breathing difficulties, needing hospital treatment. The number of hospital admissions for bronchiolitis has been increasing over the last ten years, from 21,330 admissions in England in 2004 to 30,451 in 2011. A 2013 Cochrane systematic

2018 NIHR Dissemination Centre

16. Less stringent target oxygen levels for acute bronchiolitis are safe and effective

Less stringent target oxygen levels for acute bronchiolitis are safe and effective Less stringent target oxygen levels for acute bronchiolitis are safe and effective Discover Portal Discover Portal Less stringent target oxygen levels for acute bronchiolitis are safe and effective Published on 1 December 2015 doi: This NIHR-funded trial found that acute bronchiolitis in children can be safely managed to a slightly lower target level of oxygen saturation than currently used. Setting the level (...) that this research may prompt a change in advice in due course. Share your views on the research. Why was this study needed? Bronchiolitis is a common respiratory tract infection affecting about 1 in 3 babies. About 2% to 3% of these babies develop severe breathing difficulties needing hospital treatment. The number of hospital admissions for bronchiolitis has been increasing over the last 10 years, from 21,330 admissions in England in 2004 to 30,451 in 2011. Children with bronchiolitis are treated

2018 NIHR Dissemination Centre

17. Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful

Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful Discover Portal Discover Portal Chest physiotherapy for acute bronchiolitis is ineffective and may be harmful Published on 10 May 2016 doi: Chest physiotherapy for acute bronchiolitis in children under two has no benefits and may be harmful, according to a systematic review published by the Cochrane Collaboration. The research looked (...) at three different types of chest physiotherapy. It found that none of the techniques helped children with bronchiolitis recover more quickly or led to any improvement in their condition. Some types of chest physiotherapy may make breathing and blood-oxygen levels worse. This review’s findings suggest that chest physiotherapy should not normally be used for children hospitalised with severe bronchiolitis. The findings support current NICE guidance which says that children (who don’t have another

2018 NIHR Dissemination Centre

18. A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. (PubMed)

A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis. High-flow oxygen therapy through a nasal cannula has been increasingly used in infants with bronchiolitis, despite limited high-quality evidence of its efficacy. The efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs) is unclear.In this multicenter, randomized, controlled trial, we assigned infants younger than 12 months of age who had bronchiolitis (...) differences were observed in the duration of hospital stay or the duration of oxygen therapy. In each group, one case of pneumothorax (<1% of infants) occurred. Among the 167 infants in the standard-therapy group who had treatment failure, 102 (61%) had a response to high-flow rescue therapy.Among infants with bronchiolitis who were treated outside an ICU, those who received high-flow oxygen therapy had significantly lower rates of escalation of care due to treatment failure than those in the group

Full Text available with Trip Pro

2018 NEJM

19. Bronchiolitis obliterans organising pneumonia

Bronchiolitis obliterans organising pneumonia Bronchiolitis obliterans organising pneumonia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis obliterans organising pneumonia Last reviewed: February 2019 Last updated: January 2018 Summary An inflammatory disorder involving both the peripheral bronchioles and alveoli simultaneously. It has distinctive radiographic findings, histological features (...) opacities with air bronchograms usually located peripherally. Lung biopsy may be required to establish the definitive diagnosis in patients with unusual findings or severe disease. Idiopathic BOOP is treated with corticosteroids. Cases with an underlying cause (e.g., drug-related BOOP) should have the causative factor removed; corticosteroid therapy is indicated in some cases. Definition Bronchiolitis obliterans organising pneumonia (BOOP) is defined as organised polypoid granulation tissue

2018 BMJ Best Practice

20. Bronchiolitis

Bronchiolitis Bronchiolitis - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Bronchiolitis Last reviewed: February 2019 Last updated: January 2019 Summary Leading cause of hospital admission in infants under 1 year of age. Respiratory syncytial virus (RSV) is the most common cause. Most cases are mild and self-limiting, and supportive care is the only indicated therapy. Cough may persist for weeks, after 10 to 14 days (...) of acute illness. Some patients may go on to develop recurrent wheeze. Definition Viral bronchiolitis is an acute viral infection of the lower respiratory tract. Although it can affect individuals of any age, the term is most often used to refer to infection in infancy. It is characterised by epithelial cell destruction, cellular oedema, and airway obstruction by inflammatory debris and mucus. The clinical manifestations include cough, wheeze, and laboured breathing. Respiratory syncytial virus (RSV

2018 BMJ Best Practice