Latest & greatest articles for anxiety

The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted the latest trusted evidence on anxiety or other clinical topics then use Trip today.

This page lists the very latest high quality evidence on anxiety and also the most popular articles. Popularity measured by the number of times the articles have been clicked on by fellow users in the last twelve months.

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Anxiety

Anxiety is the subjectively feelings of dread over anticipated events and it is different from fear. Clinical anxiety is a group of mental disorders with generalised anxiety disorder (GAD) being the most common (approximately 22% of primary care attendances for anxiety are classed as GAD). Overall, there is a lifetime prevalence rate of 4-7%. Anxiety can be caused by a number of factors typically classified as environmental surroundings and genetic.

In the past few decades anxiety research has significantly increased. In 2000 there were approximately 430 trials looking at anxiety and by 2015 to over 1,000. This has allowed medical professionals to develop and improve accurate diagnosis and treatments in patients suffering from the condition.

Anxiety is normal in uncomfortable environments or stressful situations. However, some individuals experience intense and persistent amounts of anxiety which needs to be kept under control. Treatments include pharmaceuticals such as SSRIs, benzodiazepines, pregabalin and gabapentin. Other therapies include CBT, acceptance and commitment therapy, and motivational interviewing.

Trip has all the latest evidence relating to treatments for anxiety, this includes systematic reviews, clinical guidelines, controlled trials, evidence-based synopses, case reports and clinical Q&As.

Top results for anxiety

1. A meta-analysis of randomized controlled trials of laughter and humour interventions on depression, anxiety and sleep quality in adults

A meta-analysis of randomized controlled trials of laughter and humour interventions on depression, anxiety and sleep quality in adults To quantify the effect of laughter and humour interventions on depression, anxiety, and sleep quality in adults.A meta-analysis of randomized controlled trials.PubMed, Embase, PsycINFO, Web of Science, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, Weipu, and Wanfang Data were searched from their inception up (...) to December 2018.The reporting of this meta-analytical review was conducted according to the guidelines of the Cochrane Collaboration. Two reviewers selected the studies, extracted the data, and evaluated the risk of bias (Cochrane Collaboration bias assessment tool) of the included papers independently.Ten studies comprising 814 participants were included. Meta-analysis showed that these interventions significantly decreased adults' depression, anxiety, and improved their sleep quality. The results

2019 EvidenceUpdates

2. Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders

Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders 4 March 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Center Portland VA Medical Center Portland, OR Mark Helfand, MD, MPH, MS, Director (...) Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders: A Systematic Review Authors: Principal Investigator: Nancy Greer, PhD Timothy J. Wilt, MD, MPH Co-Investigators: Princess Ackland, PhD, MSPH Roderick MacDonald, MS Nina Sayer, PhD Michele Spoont, PhD Brent Taylor, PhD Research Assistants: Lauren McKenzie, MPH Christina Rosebush, MPH Evidence Synthesis Program 4 Relationship

2019 Veterans Affairs Evidence-based Synthesis Program Reports

3. Generalized Anxiety Disorder. (PubMed)

Generalized Anxiety Disorder. Generalized anxiety disorder (GAD) is a common and disabling illness that is often underdiagnosed and undertreated. Patients with GAD are at increased risk for suicide as well as cardiovascular-related events and death. Most patients can be diagnosed and managed by primary care physicians. Symptoms include chronic, pervasive anxiety and worry accompanied by nonspecific physical and psychological symptoms (restlessness, fatigue, difficulty concentrating

2019 Annals of Internal Medicine

4. Clinical Reference Points for the Screen for Child Anxiety-related Disorders in 2 Investigations of Youth With Chronic Pain

Clinical Reference Points for the Screen for Child Anxiety-related Disorders in 2 Investigations of Youth With Chronic Pain Anxiety is common in pediatric chronic pain and is related to a higher risk for poor outcomes; thus, there is a need for effective clinical screening methods to identify youth with chronic pain and co-occurring anxiety. The Screen for Child Anxiety-related Disorders (SCARED) is a validated measure that defines clinically significant anxiety using the traditional clinical (...) cut-off, but in pain populations, may fail to screen in youth with subclinical anxiety that may also be at increased risk. Two studies aimed to devise a clinically meaningful approach to capture anxiety severity in pediatric chronic pain.Study 1 (n=959) and Study 2 (n=207) were completed at 2 separate pediatric pain clinics, where the SCARED was administered along with measures of disability, activity limitations, pain intensity, quality of life, and pain catastrophizing. Groups with different

2019 EvidenceUpdates

5. The Impact of 3 Different Distraction Techniques on the Pain and Anxiety Levels of Children During Venipuncture: A Clinical Trial

The Impact of 3 Different Distraction Techniques on the Pain and Anxiety Levels of Children During Venipuncture: A Clinical Trial Invasive procedures are important causes of pain and anxiety during hospitalization. This study aimed to evaluate the effect of 3 different distraction methods on the pain and anxiety levels of children during venipuncture.This was a randomized controlled trial conducted with 180 children of 6 to 10 years of age; data were collected in the months of August (...) to November 2016. Participants were randomized in 4 groups; the children in group 1 watched cartoon movies (CM), the children in group 2 played video games (VG), the children in group 3 were distracted by their parents' verbal interactions (PI), whereas no distraction method was used on the children in group 4 (control group). The levels of anxiety and pain perception were evaluated independently based on the feedback from the children, the nurse observer, and the parents. The Children Fear Scale was used

2019 EvidenceUpdates

6. A systematic review of interventions to facilitate extubation in patients difficult-to-wean due to delirium, agitation, or anxiety and a meta-analysis of the effect of dexmedetomidine

A systematic review of interventions to facilitate extubation in patients difficult-to-wean due to delirium, agitation, or anxiety and a meta-analysis of the effect of dexmedetomidine Delirium, agitation, and anxiety may hinder weaning from mechanical ventilation and lead to increased morbidity and healthcare costs. The most appropriate clinical approach to weaning in these contexts remains unclear and challenging to clinicians. The objective of this systematic review was to identify effective (...) and safe interventions to wean patients that are difficult-to-wean from mechanical ventilation due to delirium, agitation, or anxiety.A systematic review was performed using MEDLINE, EMBASE, and PubMed. Studies evaluating mechanically ventilated patients deemed difficult-to-wean due to delirium, agitation, or anxiety, and comparing the effects of an intervention with a comparator arm were sought. Time-to-extubation was the primary outcome while the secondary outcome was intensive care unit (ICU) length

2019 EvidenceUpdates

7. Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. (PubMed)

Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis. Generalised anxiety disorder is a disease that can be associated with substantial dysfunction. Pharmacological treatment is often the first choice for clinicians because of the cost and resource constraints of psychological alternatives, but there is a paucity of comparative information for the multiple available drug choices.A systematic review and network meta-analysis was performed (...) on randomised trials in adult outpatients with generalised anxiety disorder identified from MEDLINE, Web of Science, Cochrane Library, ClinicalTrials.gov, Chinese National Knowledge Infrastructure (CNKI), Wanfang data, Drugs@FDA and commercial pharmaceutical registries. Placebo and active control trials were included. Data were extracted from all manuscripts and reports. Primary outcomes were efficacy (mean difference [MD] in change in Hamilton Anxiety Scale Score) and acceptability (study discontinuations

2019 Lancet

8. Cartoons are promising for reducing dental anxiety in children

Cartoons are promising for reducing dental anxiety in children Dental anxiety in children may be reduced through cartoons Discover Portal Discover Portal Cartoons are promising for reducing dental anxiety in children Published on 3 July 2018 doi: Cartoons delivered on laptops, projectors or 3D goggles with sound can help distract anxious children who fear dental procedures. Dental anxiety can prevent children from attending the dentist for care, and this type of distraction could offer a useful (...) tool to help them. This review looked at a range of audiovisual approaches tested in trials of healthy children receiving dental treatment under local anaesthetic. The children were assessed for physiological measures related to emotional state (such as pulse rate), anxiety and observed behaviour. Childhood dental anxiety is a common problem, and these distraction approaches sound promising, safe and relatively easy to implement. Share your views on the research. Why was this study needed

2019 NIHR Dissemination Centre

9. Talking therapy may relieve high levels of anxiety about health conditions

Talking therapy may relieve high levels of anxiety about health conditions Talking therapy may relieve high levels of anxiety about health conditions Discover Portal Discover Portal Talking therapy may relieve high levels of anxiety about health conditions Published on 24 October 2017 doi: A specific talking therapy called ‘cognitive behavioural therapy for health anxiety’ may help people who are excessively worried about their health. Health anxiety reduced by a small, but meaningful amount (...) , among the medical outpatients who were identified and treated. Delivered in one-hour sessions every two weeks, therapy lasted about four months. It was provided by junior therapists and trained nurses with no previous experience of the therapy. Benefits lasted for about five years. This UK-based NIHR trial is the largest so far to screen and treat people for health anxiety in the outpatient setting. Therapy improved health anxiety, but quality of life benefits varied depending on the scale used

2019 NIHR Dissemination Centre

10. Staying on antidepressants may prevent a relapse of anxiety

Staying on antidepressants may prevent a relapse of anxiety Staying on antidepressants may prevent a relapse of anxiety Discover Portal Discover Portal Staying on antidepressants may prevent a relapse of anxiety Published on 17 January 2018 doi: People with anxiety disorders who continued taking antidepressants after successful treatment were less likely to experience a relapse, and relapsed later, than people who stopped taking antidepressants. About 16% of people had a relapse (...) if they remained on antidepressants for on average 44 weeks compared with 36% who stopped after 20 weeks. Anxiety disorders are common and can interfere with people’s everyday work, family and social life. Antidepressants and psychological therapies are the mainstays of treatment. Reducing the likelihood of relapse after successful treatment is important for the individual and the cost of additional care. There remains a need for evidence about the effectiveness of continuing treatment beyond 12 months after

2019 NIHR Dissemination Centre

11. Talking therapy given by parents shows promise for childhood anxiety disorders

Talking therapy given by parents shows promise for childhood anxiety disorders Talking therapy given by parents shows promise for childhood anxiety disorders Discover Portal Discover Portal Talking therapy given by parents shows promise for childhood anxiety disorders Published on 8 August 2017 doi: Brief guided cognitive behavioural therapy (CBT) delivered by parents was as good as a commonly used treatment, delivered by a therapist, in improving anxiety levels in children. Anxiety continued (...) to improve after the end of treatment and by six months about 70% had recovered. The brief CBT was potentially the more cost-effective option. This NIHR-funded trial compared recovery from a range of common anxiety disorders in children aged five to 12 following these brief psychological treatments. CBT was delivered by parents instructed and supported in its use by a mental health worker. It was compared with a treatment commonly used in the NHS, a solution-focused brief therapy delivered directly

2019 NIHR Dissemination Centre

12. Depression and anxiety common in people with heart disease

Depression and anxiety common in people with heart disease Depression and anxiety common in people with heart disease Discover Portal Discover Portal Depression and anxiety common in people with heart disease Published on 28 June 2016 doi: This multi-part NIHR study found that depression and anxiety were more common in people with coronary heart disease, than the general population. Anxiety increased people’s risk of a future heart attack. The people included in the study were generally older (...) , white males, so the findings may not apply to everyone. Patients considered a nurse-led intervention to personalise care was acceptable. The intervention included optimising medicines and facilitating referrals for psychological support. When asked, people with depression and coronary heart disease generally favoured non-medical treatments. These findings provide an insight into the scale of depression and anxiety amongst people with coronary heart disease. Overall costs of NHS care were increased

2019 NIHR Dissemination Centre

13. Music can reduce pain and anxiety following surgery

Music can reduce pain and anxiety following surgery Music can reduce anxiety and pain following surgery Discover Portal Discover Portal Music can reduce pain and anxiety following surgery Published on 7 August 2018 doi: Recorded music played before, during or after surgery in adults reduces self-reported post-operative pain and anxiety, compared with usual care. The average effect is equivalent to a reduction in anxiety of 21 percentage points and a 10 percentage point reduction in pain within (...) a few days of surgery. It is thought that placebo and distraction effects probably play a role, but in this review music still improved pain when used for patients under a general anaesthetic. Nearly two-thirds of patients experience severe pain after surgery. Anxiety can amplify perceptions of pain and lead to slower recovery. This systematic review included over 90 small-scale trials with a small effect, and it was not possible to blind conscious patients to which intervention they had received

2019 NIHR Dissemination Centre

14. Effect of Lavender Oil on the Anxiety of Patients Before Breast Surgery. (PubMed)

Effect of Lavender Oil on the Anxiety of Patients Before Breast Surgery. Anxiety is a common problem before surgery. This study aimed to investigate the effects of inhaling lavender oil on anxiety levels in patients before breast surgery.A randomized controlled design was used.The study was conducted in surgery clinics of a university hospital in Adana, Turkey. The study included a total of 80 patients, 40 patients in the intervention group, and 40 patients in the control group, who were (...) scheduled for breast surgery. Lavender oil was used by inhalation. A Personal Information Form and the State Anxiety Inventory were used to collect data.The mean State Anxiety Inventory pretest and post-test scores were 43.00 ± 11.48 and 37.28 ± 9.93, respectively, in the intervention group, indicating a statistically significant difference (P < .05). The mean pretest and post-test State Anxiety Inventory scores were 44.6 ± 11.45 and 42.43 ± 11.48, respectively, in the control group; however

2019 Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

15. A systematic review on the effectiveness of complementary and alternative medicine, involving massage and reflexology, for managing pain and anxiety among first-time mothers in Saudi Arabia

A systematic review on the effectiveness of complementary and alternative medicine, involving massage and reflexology, for managing pain and anxiety among first-time mothers in Saudi Arabia Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility

2019 PROSPERO

16. Anxiety in children and adolescents with chronic physical illnesses: a systematic review

Anxiety in children and adolescents with chronic physical illnesses: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files or external websites

2019 PROSPERO

17. Adult cognitive behavioural treatment outcomes across the anxiety disorders: an updated meta-analytic review

Adult cognitive behavioural treatment outcomes across the anxiety disorders: an updated meta-analytic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

18. The impact of shared decision-making in the treatment of anxiety and depression: a systematic review

The impact of shared decision-making in the treatment of anxiety and depression: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated files

2019 PROSPERO

19. The relationship between the intolerance of uncertainty and anxiety in people with autism spectrum disorder: a systematic review and meta analysis

The relationship between the intolerance of uncertainty and anxiety in people with autism spectrum disorder: a systematic review and meta analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

20. The efficacy of virtual reality systems for pain and anxiety management in surgical procedures: a systematic review

The efficacy of virtual reality systems for pain and anxiety management in surgical procedures: a systematic review Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any associated

2019 PROSPERO