Does acetaminophen affect the vaccines efficacy in infant?for general population
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- Answered 25 Aug 2019 Conflict of interest declaration: None There are lots of studies that have explored this, a few of them are below. This is not an exhaustive, more illustrative. A 2009 paper in the Lancet “Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials”  concluded: “Although febrile reactions significantly decreased, prophylactic administration of antipyretic drugs at the time of vaccination should not be routinely recommended since antibody responses to several vaccine antigens were reduced.” A 2017 paper “Prophylactic antipyretics for prevention of febrile seizures following vaccination” in the Canadian Family Physician  reported: “…children receiving these vaccinations should not receive prophylactic antipyretics, as no statistically significant reduction in the rate of febrile seizures has been documented, and prophylactic antipyretic use potentially decreases the immune response to certain vaccines.” A 2018 paper in Paediatrics & Child Health  reported: “Two recent studies showed that such prophylaxis can reduce immune responses to some infant vaccines, warranting judicious use. In contrast, implementing treatment 6 hours or more after immunization had no effect on vaccine responses and would reduce drug exposure of asymptomatic infants.” I have placed links to other articles which discuss this issue, most of which reflecting the position outlined above [4, 5, 6, 7, 8] References 1) http://www.est.ufmg.br/~enricoc/pdf/medicina/Grupo18/artigo%20do%20paracetamol.pdf 2) https://www.cfp.ca/content/63/2/128.short 3) https://academic.oup.com/pch/article/23/4/245/4925963 4) https://www.tandfonline.com/doi/full/10.1080/21645515.2016.1223001 5) https://www.sciencedirect.com/science/article/pii/S0264410X17302293 6) https://journals.lww.com/pidj/Abstract/2018/10000/Impact_of_Fever_and_Antipyretic_Use_on_Influenza.3.aspx 7) https://www.tandfonline.com/doi/full/10.1080/21645515.2016.1183077 8) https://www.ncbi.nlm.nih.gov/pubmed/29056422