Do prescription amphetamine salts increase blood pressure in patients with preexisting hypertension?
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- Answered 19 Aug 2019 Conflict of interest declaration: None Adderall is, as far as I know, an amphetamine salt. Online drug sites, such as RxList report  that “elevation of blood pressure” is a known side effect. Patient sites, such as the Mayo Clinical also report that amphetamines can be a cause of raised blood pressure . The BMJ have a news item , reporting on an article in Heart Asia , states: “Amphetamine is a stimulant, which sends the sympathetic nervous system and production of the ‘fight or flight’ hormone adrenaline into overdrive. It is associated with cardiovascular system effects, including speeding up the heart rate, sharply increasing blood pressure, and boosting the risk of stroke, heart attack, and aneurysm rupture.” Finally, the National Institute on Drug Abuse has published a document – aimed at junior scientists – that report similar findings as reported above. None of these report specifically on people with pre-existing conditions although  does state: “The effects were seen in both men and women, and irrespective of other potential risk factors for heart disease and stroke, the findings indicate.” References 1) https://www.rxlist.com/adderall-drug.htm#side_effects 2) https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/blood-pressure/art-20045245 3) https://www.bmj.com/company/newsroom/amphetamine-heart/ 4) https://heartasia.bmj.com/content/9/1/30 5) https://www.drugabuse.gov/sites/default/files/grades4-5mod4.pdf