effectivness end side effectos of ondasentron vs metoclopramide
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Thanks for your response,
Thanks for your question,
- Answered 8 Aug 2019 Conflict of interest declaration: None Unfortunately, there is not enough information to properly answer the question. A good clinical question is often helped by following the PICO format: P = population I = intervention C = comparison O = outcome The question has a clear intervention and comparison (ondansetron and metoclopramide) but the population is unclear. For instance, if you look at this Trip search https://www.tripdatabase.com/search?criteria=ondansetron+metoclopramide you'll see they see there are lots of specific populations eg post-laparoscopic surgery, pediatric emergency department, after laparoscopic cholecystectomy etc If you look at two examples: 1) Ondansetron in nausea/vomiting of pregnancy  it reports "Two RCTs from Malaysia and Iran, 160 and 83 patients respectively, found ondansetron (intravenous or oral) at least as good as metoclopramide in hyperemesis gravidarum." 2) Treatment of nausea and vomiting in adults inthe emergency department setting  states "In an ED population, there is no definite evidence to support the superiority of any one drug over any other drug, or the superiorityof any drug over placebo." If you can specify the population better it will give a better response References 1) https://gomainpro.ca/wp-content/uploads/tools-for-practice/1500655740_tfp192ondansetronfv.pdf 2) https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010106.pub2/epdf/full